Before You Continue...

A first step as you consider this study is to answer a 5-minute online questionnaire about your health and medical history. If your answers show the study might be a good fit for you, you may choose to be referred to a study clinic that you select. You will then be asked to provide your contact information for a study representative to contact you and discuss the next steps. Only the study staff can determine if you meet the study's eligibility criteria and are able to enroll in the study.

Click 'Next' to begin the questionnaire.

Question 1 of 4
Please select the age group that applies to you.
Question 2 of 4
Have you received a flu vaccine in the last 6 months?
Question 3 of 4
Have you received a COVID vaccine or booster in the last 2 months?
Question 4 of 4
Do you have a chronic medical condition that has required a change in therapy or hospitalization over the past 6 weeks?

Sorry, you are not eligible at this time...

Thank you so much for your interest in the mRNA flu vaccine study and for answering our questions.

There may be other Pfizer research studies enrolling in your area in the future. If you would like to be notified about future research opportunities, we will collect your name, phone number, and email address so that a study representative may contact you about other research studies. Your contact information will not be used for any other purposes.

The individual responses you've provided will be used by Pfizer, or our partners supporting this study, to look for areas of improvement such as revising the criteria for participation in this study. Pfizer study team members and our partners will have access to reports containing aggregated data that will not be directly linked back to you. All information is stored on servers in the United States.

So far, so good!

Please enter your information below to find a study location near you. By doing so, you also opt-in to be contacted about other future Pfizer studies. Once you select a site, the research study staff will contact you to see if you qualify to enroll.

Choose a Location
See below to select a research site near you. If you don't see a site near you, select "The sites listed here are not convenient for me." Study locations are added regularly. A study representative will contact you if a research site becomes available in your area.

Benchmark Research - Austin

3100 Red River Street, Suite 1
Austin, TX 78705
NaN Mi

Coastal Carolina Research Center

4920 O'Hear Avenue, Suite 101
North Charleston, SC 29405
NaN Mi

Diablo Clinical Research, Inc.

2255 Ygnacio Valley Road, Suite M
Walnut Creek, CA 94598
NaN Mi

Finlay Medical Research

6803 Lake Worth Road, Suite 315
Greenacres, FL 33467
NaN Mi

Martin Diagnostic Clinic

710 Lawrence Street
Tomball, TX 77375
NaN Mi

Meridian Clinical Research Omaha

3319 N 107th Street
Omaha, NE 68134
NaN Mi

Miami Clinical Research

2400 SW 69th Ave
Miami, FL 33155
NaN Mi

The sites listed here are not convenient for me.

Sorry, you are not eligible at this time...

Please enter your information below if you would like to be contacted about future clinical research opportunities.

First name must not be blank

Last name must not be blank

Please enter a valid phone number

Please enter a valid email

Please select a valid address

Please select an age range

About the saRNA Flu Vaccine Study

Today's flu vaccines are updated each year to prevent infection with the specific strains of the flu that scientists and health officials expect to be common that year. It takes several months to make the vaccines and their effectiveness depends on how well they match the strains of the flu virus that are circulating.

Recent advances in mRNA-based vaccines like the COVID-19 vaccine have taught us more about how mRNA technology can be used to develop vaccines. This research will focus on an investigational vaccine that contains a specific type of mRNA called self-amplifying RNA or saRNA. Like other mRNA vaccines, saRNA vaccines take less time to make. This means it could be easier to produce vaccines each season that are better matched to the most common flu strains. In addition to this, saRNA vaccines may be able to be given at a lower dose than other mRNA vaccines.

The creation of the COVID-19 vaccine made history. Could you help us try to do it again with flu?

The saRNA Flu Vaccine Study will help us learn if an investigational vaccine is safe and can help the body produce antibodies which may help fight off the flu. The investigational vaccine is thought to work by activating your immune system using saRNA. There is no weakened or dead flu virus in the investigational vaccine.

Your participation in this research study will not only help advance a potential new type of flu vaccine, but will support investigational vaccine development for other infectious diseases. So, thank you for taking the time to learn more.

This study is currently enrolling people who:

  • Are 18 to 49 years old
  • Are generally healthy or have stable chronic conditions
  • Have not received a flu vaccine in the last six months
  • Have not received a COVID-19 vaccine in the last two months and are not planning to receive a COVID-19 vaccine within the first two months of study participation

Be Represented

While everyone needs to be represented in vaccine clinical studies, it is especially important that these vaccine studies include people from the communities most significantly impacted by the flu. By choosing to volunteer, you will represent people like you — in age, sex, race, and ethnicity and from communities like yours. Involving people from all backgrounds will improve the development of this investigational vaccine for everyone. By volunteering for a flu vaccine study, you can make a difference.

About saRNA Vaccines

The immune system is the body's natural defense against infections. Vaccines help the immune system recognize viruses and bacteria that may invade the body in the future.

Some vaccines contain a small amount of the virus or bacteria from the disease they are designed to help prevent. The virus or bacteria has either been killed or weakened so it cannot make a person sick. Other vaccines contain only a part of the germ from the disease.

The investigational vaccine being studied is an saRNA vaccine, a type of mRNA vaccine. mRNA vaccines do not contain any killed or weakened virus. mRNA vaccines work by telling your body to produce proteins that look just like certain parts of the virus. The immune system reacts to these proteins in a similar way to a real virus. As a result, certain immune system cells "remember" how to recognize these proteins quickly and fight the real infection if it happens in the future.

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What to Expect


Study participants will receive the investigational flu vaccine, a licensed flu vaccine, or a placebo which does not contain any active ingredients.


This research study will last about seven months. Participants will visit the research site about seven times, including screening, vaccination, and follow-up visits to monitor their health.

cell phone

Over the course of the study, participants will need to report any changes in their health. To make this easier, they will be given an electronic diary (eDiary) to use, or they can download the secure eDiary app to their smartphone.


The study vaccine and study-related procedures will be provided at no cost. Participants do not need health insurance to take part. Participants will be reimbursed for any reasonable expenses they have as a result of being in this study. This may include parking, meals, or other travel related expenses.


Research studies are voluntary. Taking part in a research study is a personal choice. Participants may leave the study at any time and for any reason.

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